Rr420^tm1.1Itok
Targeted Allele Detail

Summary

• Symbol: Rr420^tm1.1Itok
• Name: regulatory region 420; targeted mutation 1.1, Kosei Ito
• MGI ID: MGI:7484530
• Synonyms: mR1^m HR
• Gene: Rr420 Location: Chr15:61856875-61856880 bp Genetic Position: Chr15, Syntenic
• Alliance: Rr420^tm1.1Itok page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:319454
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutation: Nucleotide substitutions
• Mutation details: The regulatory region sequence (TGCGGT) was replaced with a BGL II site (AGATCT) and an FRT flanked neo cassette was inserted via homologous recombination. Flp mediated recombination removed the neo cassette. (J:319454)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr420 Mutation: 0 strains or lines available

References

• Original: J:319454 Otani S, et al., Runx3 is required for oncogenic Myc upregulation in p53-deficient osteosarcoma. Oncogene. 2022 Jan;41(5):683-691
• All: 1 reference(s)