Ly6a^{tm1.1(cre/ERT2)Geno}
Targeted Allele Detail

Summary

• Symbol: Ly6a^{tm1.1(cre/ERT2)Geno}
• Name: lymphocyte antigen 6 family member A; targeted mutation 1.1, Genoway
• MGI ID: MGI:7484560
• Synonyms: Sca-1-CreERT2, Sca-1(Ly6a)-CreER^T2
• Gene: Ly6a Location: Chr15:74866726-74869880 bp, - strand Genetic Position: Chr15, 34.29 cM
• Alliance: Ly6a^{tm1.1(cre/ERT2)Geno} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:335791
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Ly6a^{tm1.1(cre/ERT2)Geno} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ly6a (MGI:107527)

• Mutation details: A cDNA encoding CreERT2 coding sequence and frt sites flanked neomycin cassette was inserted in frame of the Ly6a ATG start sequence by homologous recombination in ES cells. The neo selection sequence was later deleted by applying Flp-frt based system. (J:335791)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ly6a (mouse) Summary of all recombinase alleles driven by Ly6a. Comparative matrix view of recombinase activities Alliance mouse Ly6a gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ly6a Mutation: 22 strains or lines available

References

• Original: J:335791 Ni Z, et al., Multilineage commitment of Sca-1(+) cells in reshaping vein grafts. Theranostics. 2023;13(7):2154-2175
• All: 1 reference(s)