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Clcn1em1(IMPC)Mbp
Endonuclease-mediated Allele Detail
Summary
Symbol: Clcn1em1(IMPC)Mbp
Name: chloride channel, voltage-sensitive 1; endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
MGI ID: MGI:7484789
Gene: Clcn1  Location: Chr6:42263619-42292690 bp, + strand  Genetic Position: Chr6, 20.57 cM
Alliance: Clcn1em1(IMPC)Mbp page
IMPC: Clcn1 gene page
Mutation
origin
Strain of Origin:  C57BL/6NCrl
Project Collection: IMPC
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
Inheritance:    Not Specified
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
 
Phenotypes:
Affected Systems
show or hide all annotated terms Sex:
Source:
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IMPC - UCD
IMPC - UCD
behavior/neurological
abnormal behavior
decreased exploration in new environment
decreased thigmotaxis
decreased startle reflex
tremors
decreased grip strength
abnormal gait
decreased vertical activity
decreased locomotor activity
cardiovascular system
decreased heart weight
growth/size/body
decreased body length
hearing/vestibular/ear
abnormal auditory brainstem response
hematopoietic system
increased eosinophil cell number
decreased mean platelet volume
decreased lymphocyte cell number
decreased monocyte cell number
homeostasis/metabolism
increased circulating bilirubin level
decreased circulating glucose level
increased circulating aspartate transaminase level
increased circulating serum albumin level
abnormal cholesterol homeostasis
decreased circulating HDL cholesterol level
immune system
increased eosinophil cell number
decreased lymphocyte cell number
decreased monocyte cell number
nervous system
decreased prepulse inhibition
reproductive system
female infertility
male infertility
vision/eye
abnormal eye morphology
microphthalmia
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Clcn1 Mutation:  71 strains or lines available
References
Original:  J:265051 MGI and IMPC, MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). Database Release. 2018-2023;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory