Acot12^em1Holi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Acot12^em1Holi
• Name: acyl-CoA thioesterase 12; endonuclease-mediated mutation 1, Hongliang Li
• MGI ID: MGI:7485925
• Synonyms: Acot12^-
• Gene: Acot12 Location: Chr13:91889635-91934271 bp, + strand Genetic Position: Chr13, 47.43 cM
• Alliance: Acot12^em1Holi page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 genome editing technology was used to generate a mutation targeting introns 2 and 3. (J:335836)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acot12 Mutation: 37 strains or lines available

References

• Original: J:335836 He H, et al., Acyl-CoA thioesterase 12 suppresses YAP-mediated hepatocarcinogenesis by limiting glycerolipid biosynthesis. Cancer Lett. 2023 May 5;565:216210
• All: 1 reference(s)