Tg(Mafg-Nrf2/cre,-EGFP)737Hozu
Transgene Detail

Summary

• Symbol: Tg(Mafg-Nrf2/cre,-EGFP)737Hozu
• Name: transgene insertion 737, Hozumi Motohashi
• MGI ID: MGI:7485929
• Synonyms: MGRD-Neh2-Cre
• Transgene: Tg(Mafg-Nrf2/cre,-EGFP)737Hozu Location: unknown
• Alliance: Tg(Mafg-Nrf2/cre,-EGFP)737Hozu page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: electrophilic stress
• Mutation: Insertion
• Tg(Mafg-Nrf2/cre,-EGFP)737Hozu expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Mafg (MGI:96911)

• Mutation details: The transgene consisting of the cDNA encoding Neh2 domain of the mouse Nrf2 gene (NRF2) fused to a Cre coding sequence followed by a CL1-PEST degradation signal was linked to the IRES-EGFP fragment and inserted downstream of the Mafg-regulatory domain (MGRD). Four founder progenies were obtained, and one of the transgenic mouse lines (line# 737) was selected and used for the studies. (J:331370)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Mafg (mouse) Summary of all recombinase alleles driven by Mafg. Comparative matrix view of recombinase activities Alliance mouse Mafg gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:331370 Kitamura H, et al., Establishment of Neh2-Cre:tdTomato reporter mouse for monitoring the exposure history to electrophilic stress. Free Radic Biol Med. 2022 Nov 9;193(Pt 2):610-619
• All: 1 reference(s)