Itgb3bp^tm1.1Tfw
Targeted Allele Detail

Summary

• Symbol: Itgb3bp^tm1.1Tfw
• Name: integrin beta 3 binding protein (beta3-endonexin); targeted mutation 1.1, Tatsuo Fukagawa
• MGI ID: MGI:7486275
• Synonyms: Cenp-r^-, Itgb3bp^tm1.1Yuwa
• Gene: Itgb3bp Location: Chr4:99655643-99717403 bp, - strand Genetic Position: Chr4, 45.71 cM, cytoband C6
• Alliance: Itgb3bp^tm1.1Tfw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:271187
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The selection maker Beta-geo flanked by loxP sites was inserted in the 5 end of exon 4 and a third loxP site was inserted in the 3 end of exon 4. Exon 4 and the beta-geo selection marker were removed via cre-mediated recombination. Western blot analysis confirmed absence of protein. (J:271187)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Itgb3bp Mutation: 16 strains or lines available

References

• Original: J:271187 Okumura K, et al., CENP-R acts bilaterally as a tumor suppressor and as an oncogene in the two-stage skin carcinogenesis model. Cancer Sci. 2017 Nov;108(11):2142-2148
• All: 1 reference(s)