About   Help   FAQ
Itgb3bptm1.1Tfw
Targeted Allele Detail
Summary
Symbol: Itgb3bptm1.1Tfw
Name: integrin beta 3 binding protein (beta3-endonexin); targeted mutation 1.1, Tatsuo Fukagawa
MGI ID: MGI:7486275
Synonyms: Cenp-r-, Itgb3bptm1.1Yuwa
Gene: Itgb3bp  Location: Chr4:99655643-99717403 bp, - strand  Genetic Position: Chr4, 45.71 cM, cytoband C6
Alliance: Itgb3bptm1.1Tfw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:271187
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe selection maker Beta-geo flanked by loxP sites was inserted in the 5 end of exon 4 and a third loxP site was inserted in the 3 end of exon 4. Exon 4 and the beta-geo selection marker were removed via cre-mediated recombination. Western blot analysis confirmed absence of protein. (J:271187)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itgb3bp Mutation:  16 strains or lines available
References
Original:  J:271187 Okumura K, et al., CENP-R acts bilaterally as a tumor suppressor and as an oncogene in the two-stage skin carcinogenesis model. Cancer Sci. 2017 Nov;108(11):2142-2148
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory