Tpcn2^{tm1.1(cre)Lrcb}
Targeted Allele Detail

Summary

• Symbol: Tpcn2^{tm1.1(cre)Lrcb}
• Name: two pore segment channel 2; targeted mutation 1.1, Christian Grimm
• MGI ID: MGI:7486452
• Synonyms: TPC2-IRES-Cre
• Gene: Tpcn2 Location: Chr7:144740261-144837748 bp, - strand Genetic Position: Chr7, 89.02 cM
• Alliance: Tpcn2^{tm1.1(cre)Lrcb} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:329280
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Tpcn2^{tm1.1(cre)Lrcb} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tpcn2 (MGI:2385297)

• Mutation details: The IRES-Cre-FRT-pgk-Neo-FRT cassette was inserted at 5 bp after the stop codon in exon 25 of the Tpcn2 gene. The resulting mice were crossed with FLP deleter mice to remove the neo cassette. (J:329280)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tpcn2 (mouse) Summary of all recombinase alleles driven by Tpcn2. Comparative matrix view of recombinase activities Alliance mouse Tpcn2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tpcn2 Mutation: 52 strains or lines available

References

• Original: J:329280 Scotto Rosato A, et al., TPC2 rescues lysosomal storage in mucolipidosis type IV, Niemann-Pick type C1, and Batten disease. EMBO Mol Med. 2022 Sep 7;14(9):e15377
• All: 1 reference(s)