Mul1^tm1.1Hmmc
Targeted Allele Detail

Summary

• Symbol: Mul1^tm1.1Hmmc
• Name: mitochondrial ubiquitin ligase activator of NFKB 1; targeted mutation 1.1, Heidi M McBride
• MGI ID: MGI:7486477
• Gene: Mul1 Location: Chr4:138161982-138169576 bp, + strand Genetic Position: Chr4, 70.28 cM
• Alliance: Mul1^tm1.1Hmmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:336080
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 2 was flanked by loxP sites and was removed via cre-mediated recombination in the germline. (J:336080)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mul1 Mutation: 16 strains or lines available

References

• Original: J:336080 Doiron K, et al., The dynamic interacting landscape of MAPL reveals essential functions for SUMOylation in innate immunity. Sci Rep. 2017 Mar 7;7(1):107
• All: 2 reference(s)