Braftm1.1Tumg
Targeted Allele Detail
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Symbol: |
Braftm1.1Tumg |
Name: |
Braf transforming gene; targeted mutation 1.1, Yoko Aoki |
MGI ID: |
MGI:7488140 |
Synonyms: |
Braftm1.1(Q241R)Tumg |
Gene: |
Braf Location: Chr6:39580171-39702397 bp, - strand Genetic Position: Chr6, 18.43 cM
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Alliance: |
Braftm1.1Tumg page
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Germline Transmission: |
Earliest citation of germline transmission:
J:216228
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6J
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Allele Type: |
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Targeted (Not Applicable) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: A PGK-Neo-STOP cassette flanked by loxP sites was inserted in intron 6 and a glutamine to arginine substitution at amino acid 241 (Q241R) was inserted into exon 7 via homologous recombination. The mutant transcript is expressed after cre-mediated recombination.
(J:216228)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Braf Mutation: |
58 strains or lines available
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Original: |
J:216228 Inoue S, et al., New BRAF knockin mice provide a pathogenetic mechanism of developmental defects and a therapeutic approach in cardio-facio-cutaneous syndrome. Hum Mol Genet. 2014 Dec 15;23(24):6553-66 |
All: |
1 reference(s) |
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