Nrg1^tm1Jya
Targeted Allele Detail

Summary

• Symbol: Nrg1^tm1Jya
• Name: neuregulin 1; targeted mutation 1, Junji Yamauchi
• MGI ID: MGI:7488428
• Synonyms: NRG1 type III^-
• Gene: Nrg1 Location: Chr8:32299493-33381858 bp, - strand Genetic Position: Chr8, 18.75 cM
• Alliance: Nrg1^tm1Jya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:250872
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct replaced exon 1 with an FRT- and loxP-flanked neomycin resistance cassette. The allele does not expresses the type 3 isoform. (J:250872)

Expression

In Mice Carrying this Mutation:

9 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrg1 Mutation: 54 strains or lines available

References

• Original: J:250872 Miyamoto Y, et al., Neuregulin-1 type III knockout mice exhibit delayed migration of Schwann cell precursors. Biochem Biophys Res Commun. 2017 Apr 29;486(2):506-513
• All: 1 reference(s)