Crybb1^em1(icre)Cln
Endonuclease-mediated Allele Detail

Summary

• Symbol: Crybb1^em1(icre)Cln
• Name: crystallin, beta B1; endonuclease-mediated mutation 1, Marco Colonna
• MGI ID: MGI:7488430
• Synonyms: Crybb1-Cre
• Gene: Crybb1 Location: Chr5:112403686-112417451 bp, + strand Genetic Position: Chr5, 54.63 cM
• Alliance: Crybb1^em1(icre)Cln page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout, Recombinase)
• Mutations: Insertion, Intragenic deletion
• Crybb1^em1(icre)Cln expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Crybb1 (MGI:104992)

• Mutation details: Using CRISPR/Cas9 endonuclease-mediated genome editing, a codon-optimized iCre and polyA sequences replaced the exon 1 of the crystallin, beta B1 (Crybb1) gene on chromosome 5. (J:334326)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Crybb1 (mouse) Summary of all recombinase alleles driven by Crybb1. Comparative matrix view of recombinase activities Alliance mouse Crybb1 gene page

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Crybb1 Mutation: 10 strains or lines available

References

• Original: J:334326 Brioschi S, et al., A Cre-deleter specific for embryo-derived brain macrophages reveals distinct features of microglia and border macrophages. Immunity. 2023 Feb 8
• All: 1 reference(s)