Mecom^{em1(cre/ERT2)Suda}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mecom^{em1(cre/ERT2)Suda}
• Name: MDS1 and EVI1 complex locus; endonuclease-mediated mutation 1, Toshio Suda
• MGI ID: MGI:7488471
• Synonyms: Evi1^creERT2
• Gene: Mecom Location: Chr3:30005445-30563937 bp, - strand Genetic Position: Chr3, 12.66 cM
• Alliance: Mecom^{em1(cre/ERT2)Suda} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Mecom^{em1(cre/ERT2)Suda} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Mecom (MGI:95457)

• Mutation details: Using the CRISPR/Cas9 method, a murine Mecom cDNA (encoding exons 9 through 15) followed by 15)-P2A-creERT2 gene fusion was inserted into exon 9. (J:336140)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Mecom (mouse) Summary of all recombinase alleles driven by Mecom. Comparative matrix view of recombinase activities Alliance mouse Mecom gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mecom Mutation: 81 strains or lines available

References

• Original: J:336140 Yokomizo T, et al., Independent origins of fetal liver haematopoietic stem and progenitor cells. Nature. 2022 Sep;609(7928):779-784
• All: 1 reference(s)