Lepr^{em2(cre/ERT2)Smoc}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lepr^{em2(cre/ERT2)Smoc}
• Name: leptin receptor; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
• MGI ID: MGI:7489534
• Synonyms: LeprB-CreER, Lepr-CreER
• Gene: Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
• Alliance: Lepr^{em2(cre/ERT2)Smoc} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Lepr^{em2(cre/ERT2)Smoc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Lepr (MGI:104993)

• Mutation details: IRES-iCreERT2 construct was inserted after exon 19 stop codon of Lepr gene. No molecular details are provided. (J:327115)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lepr (mouse) Summary of all recombinase alleles driven by Lepr. Comparative matrix view of recombinase activities Alliance mouse Lepr gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lepr Mutation: 122 strains or lines available

References

• Original: J:327115 Liu Y, et al., Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state. Dev Cell. 2022 Jul 25;57(14):1758-1775.e7
• All: 1 reference(s)