Pou4f1^{tm1(flpo/ERT2)Past}
Targeted Allele Detail

Summary

• Symbol: Pou4f1^{tm1(flpo/ERT2)Past}
• Name: POU domain, class 4, transcription factor 1; targeted mutation 1, Jeroen Pasterkamp
• MGI ID: MGI:7489615
• Synonyms: Brn3a-mTurquoiseHIS-FlpO^ERT2
• Gene: Pou4f1 Location: Chr14:104699112-104705435 bp, - strand Genetic Position: Chr14, 54.21 cM, cytoband E1-E3
• Alliance: Pou4f1^{tm1(flpo/ERT2)Past} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:326542
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Pou4f1^{tm1(flpo/ERT2)Past} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pou4f1 (MGI:102525)

• Mutation details: The targeting vector consists of a T2A-mTurquoiseHIS-P2A-FlpO fragment inserted upstream of a lox511-Neo-lox511 cassette was targeted into the Pou4f1 (Brn3a) gene by homologous recombination in ES cells. (J:326542)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pou4f1 (mouse) Summary of all recombinase alleles driven by Pou4f1. Comparative matrix view of recombinase activities Alliance mouse Pou4f1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pou4f1 Mutation: 13 strains or lines available

References

• Original: J:326542 van de Haar LL, et al., Molecular signatures and cellular diversity during mouse habenula development. Cell Rep. 2022 Jul 5;40(1):111029
• All: 1 reference(s)