Abcc9^{em2(cre/ERT2)Cbet}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Abcc9^{em2(cre/ERT2)Cbet}
• Name: ATP-binding cassette, sub-family C member 9; endonuclease-mediated mutation 2, Christer Betsholtz
• MGI ID: MGI:7489797
• Synonyms: Abcc9-CreERT2
• Gene: Abcc9 Location: Chr6:142533588-142648041 bp, - strand Genetic Position: Chr6, 74.35 cM
• Alliance: Abcc9^{em2(cre/ERT2)Cbet} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Abcc9^{em2(cre/ERT2)Cbet} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Abcc9 (MGI:1352630)

• Mutation details: Using CRISPR targeting homologous recombination, the P2A-CreERT2 sequence was inserted at the location between the last amino acid and the translation termination codon in exon 40 of the Abcc9 gene. (J:325735)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Abcc9 (mouse) Summary of all recombinase alleles driven by Abcc9. Alliance mouse Abcc9 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abcc9 Mutation: 101 strains or lines available

References

• Original: J:325735 Ando K, et al., KCNJ8/ABCC9-containing K-ATP channel modulates brain vascular smooth muscle development and neurovascular coupling. Dev Cell. 2022 Jun 6;57(11):1383-1399.e7
• All: 1 reference(s)