Chd7^em1Kangn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Chd7^em1Kangn
• Name: chromodomain helicase DNA binding protein 7; endonuclease-mediated mutation 1, Ning Kang
• MGI ID: MGI:7489804
• Synonyms: Chd7^fl
• Gene: Chd7 Location: Chr4:8690406-8867659 bp, + strand Genetic Position: Chr4, 3.68 cM
• Alliance: Chd7^em1Kangn page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• CRISPR-cas9 mediated recombination using guide RNAs introduced loxP sites around exon 2. (J:336448)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chd7 Mutation: 138 strains or lines available

References

• Original: J:336448 Liu C, et al., CHD7 regulates bone-fat balance by suppressing PPAR-gamma signaling. Nat Commun. 2022 Apr 13;13(1):1989
• All: 1 reference(s)