Foxn2^em1(IMPC)Tcp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Foxn2^em1(IMPC)Tcp
• Name: forkhead box N2; endonuclease-mediated mutation 1, The Centre for Phenogenomics
• MGI ID: MGI:7490165
• Gene: Foxn2 Location: Chr17:88748139-88797961 bp, + strand Genetic Position: Chr17, 57.97 cM, cytoband E5
• Alliance: Foxn2^em1(IMPC)Tcp page
• IMPC: Foxn2 gene page

Mutation origin

• Strain of Origin: C57BL/6NCrl
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Centre for Phenogenomics by electroporating Cas9 ribonucleoprotein complexes with single guide RNAs having spacer sequences of TGTATGCTCTAACCCAAGAT targeting the 5' side and CACTGGGGCAAAAGCGTGGT targeting the 3' side of a critical region (ENSMUSE00001274531). This resulted in a 1661-bp deletion of Chr17 from 88783208 to 88784868 (GRCm39), introducing a frameshift and premature stop codon. (J:265051)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Foxn2 Mutation: 35 strains or lines available

References

• Original: J:265051 MGI and IMPC, MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). Database Release. 2018-2023
• All: 2 reference(s)