Scn9a^{em1(icre)Itsu}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Scn9a^{em1(icre)Itsu}
• Name: sodium channel, voltage-gated, type IX, alpha; endonuclease-mediated mutation 1, Isao Tsuneyoshi
• MGI ID: MGI:7490200
• Synonyms: NaV1.7-iCre, NaV1.7^iCre
• Gene: Scn9a Location: Chr2:66310424-66465306 bp, - strand Genetic Position: Chr2, 39.13 cM
• Alliance: Scn9a^{em1(icre)Itsu} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Scn9a^{em1(icre)Itsu} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Scn9a (MGI:107636)

• Mutation details: Using the CRISPR/Cas9 system, a P2A-iCre-rabbit globin polyadenylation sequence was inserted after the last exon of the Scn9a gene. (J:330040)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Scn9a (mouse) Summary of all recombinase alleles driven by Scn9a. Comparative matrix view of recombinase activities Alliance mouse Scn9a gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn9a Mutation: 121 strains or lines available

References

• Original: J:330040 Maruta T, et al., Selective optogenetic activation of NaV1.7-expressing afferents in NaV1.7-ChR2 mice induces nocifensive behavior without affecting responses to mechanical and thermal stimuli. PLoS One. 2022;17(10):e0275751
• All: 1 reference(s)