Cd40lg^{tm1.1(icre)Tega}
Targeted Allele Detail

Summary

• Symbol: Cd40lg^{tm1.1(icre)Tega}
• Name: CD40 ligand; targeted mutation 1.1, Takeshi Egawa
• MGI ID: MGI:7490227
• Synonyms: Cd40lg-cre
• Gene: Cd40lg Location: ChrX:56257503-56269402 bp, + strand Genetic Position: ChrX, 31.21 cM
• Alliance: Cd40lg^{tm1.1(icre)Tega} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:327502
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Cd40lg^{tm1.1(icre)Tega} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cd40lg (MGI:88337)

• Mutation details: An IRES-icre sequence was inserted into the 3 UTR of the Cd40lg gene by homologous recombination. After obtaining germline transmission of the targeted allele, the FRT-flanked selection cassette was removed by crossing to Flpe transgenic mice. (J:327502)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cd40lg (mouse) Summary of all recombinase alleles driven by Cd40lg. Comparative matrix view of recombinase activities Alliance mouse Cd40lg gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd40lg Mutation: 17 strains or lines available

References

• Original: J:327502 Xia Y, et al., BCL6-dependent TCF-1(+) progenitor cells maintain effector and helper CD4(+) T cell responses to persistent antigen. Immunity. 2022 Jul 12;55(7):1200-1215.e6
• All: 1 reference(s)