Tg(Gm5127-cre/ERT2)1Mhsi
Transgene Detail

Summary

• Symbol: Tg(Gm5127-cre/ERT2)1Mhsi
• Name: transgene insertion 1, Michael Simons
• MGI ID: MGI:7490280
• Synonyms: Gm5127(BAC)CreERT2
• Transgene: Tg(Gm5127-cre/ERT2)1Mhsi Location: unknown
• Alliance: Tg(Gm5127-cre/ERT2)1Mhsi page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL/J)F2

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Gm5127-cre/ERT2)1Mhsi expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gm5127 (MGI:3648285)

• Mutation details: The bacterial artificial chromosome, RP23-113I19, containing the Gm5127 predicted gene (including 27 kb of 5' upstream and 70 kb of 3' downstream) was modified by recombineering to insert an inducible cre recombinase/ERT2 cassette (pCAG-CreERT2) and a FRT flanked neomycin cassette (with 50 bp overhangs) into the start codon of the Gm5127 gene sequence. (J:336605)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gm5127 (mouse) Summary of all recombinase alleles driven by Gm5127. Comparative matrix view of recombinase activities Alliance mouse Gm5127 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:336605 Lee HW, et al., Role of Venous Endothelial Cells in Developmental and Pathologic Angiogenesis. Circulation. 2021 Oct 19;144(16):1308-1322
• All: 1 reference(s)