Ctnnb1tm1.1Smoc
Targeted Allele Detail
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Symbol: |
Ctnnb1tm1.1Smoc |
Name: |
catenin beta 1; targeted mutation 1.1, Shanghai Model Organisms Center |
MGI ID: |
MGI:7490339 |
Synonyms: |
Ctnnb1T40D |
Gene: |
Ctnnb1 Location: Chr9:120762466-120789573 bp, + strand Genetic Position: Chr9, 72.19 cM
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Alliance: |
Ctnnb1tm1.1Smoc page
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Germline Transmission: |
Earliest citation of germline transmission:
J:322311
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Not Specified) |
Mutations: |
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Insertion, Intragenic deletion, Nucleotide substitutions
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Mutation details: LoxP sites were inserted into intron 1 and downstream of exon 15. Exons 2-15 were subsequently replaced with the cDNA sequence coding for exon 2-15 sequence containing a p.T40D mutation. Aspartic acid (D) is a phosphomimic and confers constitutive phosphorylation state upon the encoded peptide.
(J:322311)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ctnnb1 Mutation: |
48 strains or lines available
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Original: |
J:322311 Zhang H, et al., An MST4-pbeta-Catenin(Thr40) Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis. Adv Sci (Weinh). 2021 Sep;8(17):e2004850 |
All: |
1 reference(s) |
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