Ctnnb1^tm1.1Smoc
Targeted Allele Detail

Summary

• Symbol: Ctnnb1^tm1.1Smoc
• Name: catenin beta 1; targeted mutation 1.1, Shanghai Model Organisms Center
• MGI ID: MGI:7490339
• Synonyms: Ctnnb1^T40D
• Gene: Ctnnb1 Location: Chr9:120762466-120789573 bp, + strand Genetic Position: Chr9, 72.19 cM
• Alliance: Ctnnb1^tm1.1Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:322311
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Intragenic deletion, Nucleotide substitutions
• Mutation details: LoxP sites were inserted into intron 1 and downstream of exon 15. Exons 2-15 were subsequently replaced with the cDNA sequence coding for exon 2-15 sequence containing a p.T40D mutation. Aspartic acid (D) is a phosphomimic and confers constitutive phosphorylation state upon the encoded peptide. (J:322311)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctnnb1 Mutation: 49 strains or lines available

References

• Original: J:322311 Zhang H, et al., An MST4-pbeta-Catenin(Thr40) Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis. Adv Sci (Weinh). 2021 Sep;8(17):e2004850
• All: 1 reference(s)