Tg(Esm1-icre/ERT2)27Rha
Transgene Detail

Summary

• Symbol: Tg(Esm1-icre/ERT2)27Rha
• Name: transgene insertion 27, Ralf H Adams
• MGI ID: MGI:7490347
• Synonyms: Esm1(BAC)^iCreERT2, Esm1-iCreERT2, Esm1^iCreERT2, Esm1(PAC)CreERT2
• Transgene: Tg(Esm1-icre/ERT2)27Rha Location: unknown
• Alliance: Tg(Esm1-icre/ERT2)27Rha page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Mutation: Insertion
• Tg(Esm1-icre/ERT2)27Rha expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Esm1 (MGI:1918940)

• Mutation details: The tamoxifen-inducible iCreERT2 was inserted into a start codon of the Esm1 gene in BAC clone RP24-560I14. Two founders were obtained of which only one (founder #27) presented transmission of the transgene to offspring. (J:246778)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Esm1 (mouse) Summary of all recombinase alleles driven by Esm1. Comparative matrix view of recombinase activities Alliance mouse Esm1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:246778 Rocha SF, et al., Esm1 modulates endothelial tip cell behavior and vascular permeability by enhancing VEGF bioavailability. Circ Res. 2014 Aug 29;115(6):581-90
• All: 3 reference(s)