Piezo1^{em2(cre/ERT2)Smoc}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Piezo1^{em2(cre/ERT2)Smoc}
• Name: piezo-type mechanosensitive ion channel component 1; endonuclease-mediated mutation 1, Bin Zhou
• MGI ID: MGI:7491978
• Synonyms: Piezo1-CreER
• Gene: Piezo1 Location: Chr8:123208437-123278068 bp, - strand Genetic Position: Chr8, 71.31 cM
• Alliance: Piezo1^{em2(cre/ERT2)Smoc} page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Piezo1^{em2(cre/ERT2)Smoc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Piezo1 (MGI:3603204)

• Mutation details: Using CRISPR/Cas9 system, the CreERT2-P2A-BFP-WPRE-polyA was inserted after the start codon ATG of the gene Piezo1 by homologous recombination. (J:326492)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Piezo1 (mouse) Summary of all recombinase alleles driven by Piezo1. Comparative matrix view of recombinase activities Alliance mouse Piezo1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Piezo1 Mutation: 89 strains or lines available

References

• Original: J:326492 Li X, et al., Generation of Piezo1-CreER transgenic mice for visualization and lineage tracing of mechanical force responsive cells in vivo. Genesis. 2022 May;60(4-5):e23476
• All: 1 reference(s)