Tg(Rorc-mCherry,-cre/ERT2)#Litt
Transgene Detail

Summary

• Symbol: Tg(Rorc-mCherry,-cre/ERT2)#Litt
• Name: transgene insertion, Dan R Littman
• MGI ID: MGI:7493594
• Synonyms: RorgtTg(Rorgt-Cherry-CreERT2)
• Transgene: Tg(Rorc-mCherry,-cre/ERT2)#Litt Location: unknown
• Alliance: Tg(Rorc-mCherry,-cre/ERT2)#Litt page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Rorc-mCherry,-cre/ERT2)#Litt expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Rorc (MGI:104856)

• Tg(Rorc-mCherry,-cre/ERT2)#Litt expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Rorc (MGI:104856)

• Mutation details: The BAC clone RP24-209K20 containing mouse Rorc genomic sequence was modified such that Rorc translational start site ATG was linked to the mCherry-P2A-iCreERT2 followed by intact genomic coding and cis-regulatory sequence of Rorc gene. Line numbers were not indicated. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:336987)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Rorc (mouse) Summary of all recombinase alleles driven by Rorc. Alliance mouse Rorc gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:336987 Hall JA, et al., Transcription factor RORalpha enforces stability of the Th17 cell effector program by binding to a Rorc cis-regulatory element. Immunity. 2022 Nov 8;55(11):2027-2043.e9
• All: 1 reference(s)