Dipk1c^em1Yxy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dipk1c^em1Yxy
• Name: divergent protein kinase domain 1C; endonuclease-mediated mutation 1, Yuxin Yin
• MGI ID: MGI:7493848
• Synonyms: Fam69c^-
• Gene: Dipk1c Location: Chr18:84737361-84758561 bp, + strand Genetic Position: Chr18, 57.53 cM
• Alliance: Dipk1c^em1Yxy page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 16-bp deletion (TGGCAATGGCGCGGGC) including the translation start codon ATG. No off-target effects from top predicted sites were found. Western blot analysis confirmed absence of protein in the cortex and hippocampus. (J:328853)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dipk1c Mutation: 14 strains or lines available

References

• Original: J:328853 Mei F, et al., FAM69C, a kinase critical for synaptic function and memory, is defective in neurodegenerative dementia. Cell Rep. 2022 Jul 19;40(3):111101
• All: 2 reference(s)