Gt(ROSA)26Sor^tm1(Il33)Gpa
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm1(Il33)Gpa
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Gaby Palmer
• MGI ID: MGI:7493922
• Synonyms: Gt(ROSA)26Sor^{tm1(mIl33)Gpal}, ROSA-stop-flox-IL33
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm1(Il33)Gpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:329735
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^tm1(Il33)Gpa expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Il33 (MGI:1924375)

• Gt(ROSA)26Sor^tm1(Il33)Gpa expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gt(ROSA)26Sor (MGI:104735)

• Mutation details: A LoxP-flanked stop cassette and mouse Il33 cDNA were inserted in frame into the gene. Upon cre-mediated recombination, Il33 is expressed under the control of the endogenous Gt(ROSA)26Sor locus promoter. (J:329735)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 958 strains or lines available

References

• Original: J:329735 Talabot-Ayer D, et al., Severe neutrophil-dominated inflammation and enhanced myelopoiesis in IL-33-overexpressing CMV/IL33 mice. J Immunol. 2015 Jan 15;194(2):750-60
• All: 1 reference(s)