Pabir1^em1.1Yhua
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pabir1^em1.1Yhua
• Name: PP2A A alpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1; endonuclease-mediated mutation 1.1, Ying Huang
• MGI ID: MGI:7494133
• Synonyms: Fam122a^flox
• Gene: Pabir1 Location: Chr19:24453866-24454720 bp, - strand Genetic Position: Chr19, 19.53 cM, cytoband C1
• Alliance: Pabir1^em1.1Yhua page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: An artificial intron containing one loxP site was inserted into the middle of the single exon along with an FRT-flanked neomycin selection cassette to form two separated parts and a second loxP site was inserted into the 3-UTR region of the gene via CRISPR/Cas9 technology. The neomycin selection cassette was removed via flp-mediated recombination. (J:337217, J:337007)

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pabir1 Mutation: 5 strains or lines available

References

• Original: J:337217 Liu MH, et al., FAM122A is required for hematopoietic stem cell function. Leukemia. 2021 Jul;35(7):2130-2134
• All: 2 reference(s)