Chic1^em1(IMPC)Tcp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Chic1^em1(IMPC)Tcp
• Name: cysteine-rich hydrophobic domain 1; endonuclease-mediated mutation 1, The Centre for Phenogenomics
• MGI ID: MGI:7494199
• Gene: Chic1 Location: ChrX:102400082-102439698 bp, + strand Genetic Position: ChrX, 46.08 cM
• Alliance: Chic1^em1(IMPC)Tcp page
• IMPC: Chic1 gene page

Mutation origin

• Strain of Origin: C57BL/6NCrl
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Centre for Phenogenomics by electroporating Cas9 ribonucleoprotein complexes with single guide RNAs having spacer sequences of AGCACTGAGAACGACATGAG targeting the 5' side and ACAATTACAGCTACCTGCGC targeting the 3' side of a critical region (ENSMUSE102410139). This resulted in a 1393-bp deletion of ChrX from 102408747 to 102410139 with the insertion of 102410139 (GRCm39), introducing a frameshift and premature stop codon. (J:265051)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Chic1 Mutation: 11 strains or lines available

References

• Original: J:265051 MGI and IMPC, MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). Database Release. 2018-2023
• All: 2 reference(s)