Adad1^em1Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Adad1^em1Osb
• Name: adenosine deaminase domain containing 1; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:7495727
• Synonyms: Adad1^-
• Gene: Adad1 Location: Chr3:37117805-37165661 bp, + strand Genetic Position: Chr3, 18.3 cM, cytoband B
• Alliance: Adad1^em1Osb page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology using two sgRNAs which target the second and the twelfth exons, respectively, was employed to generate a 47612 bp deletion of the entire coding region. No protein band was immunodetected in homozygous null testes. (J:337548)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Adad1 Mutation: 29 strains or lines available

References

• Original: J:337548 Lu Y, et al., ADAD2 functions in spermiogenesis and piRNA biogenesis in mice. Andrology. 2023 May;11(4):698-709
• All: 1 reference(s)