Adad2^em1Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Adad2^em1Osb
• Name: adenosine deaminase domain containing 2; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:7495729
• Synonyms: Adad2^-, Adad2-3959 bp
• Gene: Adad2 Location: Chr8:120339486-120343663 bp, + strand Genetic Position: Chr8, 68.05 cM, cytoband E1
• Alliance: Adad2^em1Osb page

Mutation origin

• Strain of Origin: B6D2F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a 3959 bp deletion of the entire coding region. No protein band was immunodetected in testis lysates from homozygous null males. (J:337548)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Adad2 Mutation: 19 strains or lines available

References

• Original: J:337548 Lu Y, et al., ADAD2 functions in spermiogenesis and piRNA biogenesis in mice. Andrology. 2023 May;11(4):698-709
• All: 1 reference(s)