Adad2^em2Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Adad2^em2Osb
• Name: adenosine deaminase domain containing 2; endonuclease-mediated mutation 2, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:7495733
• Synonyms: Adad2^delta
• Gene: Adad2 Location: Chr8:120339486-120343663 bp, + strand Genetic Position: Chr8, 68.05 cM, cytoband E1
• Alliance: Adad2^em2Osb page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a frameshift mutation (-27 + 2 bp) at the first coding exon. No protein band was immunodetected in testis lysates from homozygous mutant males. (J:337548)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adad2 Mutation: 19 strains or lines available

References

• Original: J:337548 Lu Y, et al., ADAD2 functions in spermiogenesis and piRNA biogenesis in mice. Andrology. 2023 May;11(4):698-709
• All: 1 reference(s)