Dis3l2^em1Dean
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dis3l2^em1Dean
• Name: DIS3 like 3'-5' exoribonuclease 2; endonuclease-mediated mutation 1, Jurien Dean
• MGI ID: MGI:7495776
• Synonyms: Dis3l2 floxed
• Gene: Dis3l2 Location: Chr1:86631530-86977817 bp, + strand Genetic Position: Chr1, 43.99 cM
• Alliance: Dis3l2^em1Dean page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 genome editing technology was used to insert loxP sites flanking exon 2. qPCR confirmed the depletion of Dis3l2 transcripts in growing and fully grown germinal vesicle (GV) oocytes. (J:337555)

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dis3l2 Mutation: 58 strains or lines available

References

• Original: J:337555 Wu D, et al., DIS3L2 ribonuclease degrades terminal-uridylated RNA to ensure oocyte maturation and female fertility. Nucleic Acids Res. 2023 Apr 24;51(7):3078-3093
• All: 1 reference(s)