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Frey1em1Osb
Endonuclease-mediated Allele Detail
Summary
Symbol: Frey1em1Osb
Name: Frey regulator of sperm-oocyte fusion 1; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
MGI ID: MGI:7495885
Synonyms: 1700029I15Rik-, 1700029I15Rikem1Osb
Gene: Frey1  Location: Chr2:92213263-92213948 bp, + strand  Genetic Position: Chr2, 50.99 cM
Alliance: Frey1em1Osb page
Mutation
origin
Strain of Origin:  B6D2F1
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCRISPR/Cas9 genome editing technology was used to generate a 619-bp deletion in the coding region, resulting in translation of an incorrect amino acid sequence. Western blot analysis confirmed the absence of protein expression in homozygous null testes. (J:337566)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Frey1 Mutation:  8 strains or lines available
References
Original:  J:337566 Lu Y, et al., 1700029I15Rik orchestrates the biosynthesis of acrosomal membrane proteins required for sperm-egg interaction. Proc Natl Acad Sci U S A. 2023 Feb 21;120(8):e2207263120
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory