Rorb^hstp-2J
Spontaneous Allele Detail

Summary

• Symbol: Rorb^hstp-2J
• Name: RAR-related orphan receptor beta; high stepper 2 Jackson
• MGI ID: MGI:7495931
• Synonyms: h4
• Gene: Rorb Location: Chr19:18907969-19088560 bp, - strand Genetic Position: Chr19, 13.28 cM
• Alliance: Rorb^hstp-2J page

Mutation origin

• Strain of Origin: B6.129S7-Il1r1^tm1Imx/J

Mutation description

• Allele Type: Spontaneous (Modified isoform(s), Null/knockout)
• Mutation: Single point mutation
• Mutation details: This spontaneous guanine to adenine substitution in exon 8 replaces a cysteine with a premature stop codon that is predicted to impact both Rorb isoforms ENSMUST00000040153.15 (Rorb-201) and ENSMUST00000112832.8 (Rorb-202). Lower than normal levels of transcript are found in brain and lower than normal levels of the Rorb2 transcript are found in the retina (J:337403)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rorb Mutation: 41 strains or lines available

References

• Original: J:337403 Murray GC, et al., An allelic series of spontaneous Rorb mutant mice exhibit a gait phenotype, changes in retina morphology and behavior, and gene expression signatures associated with the unfolded protein response. G3 (Bethesda). 2023 Jun 10
• All: 1 reference(s)