Tg(Prrx1-mTFP1,-cre/ERT2)1Etnka
Transgene Detail

Summary

• Symbol: Tg(Prrx1-mTFP1,-cre/ERT2)1Etnka
• Name: transgene insertion 1, Elly M Tanaka
• MGI ID: MGI:7507547
• Synonyms: Prrx1 enhancer-CreER-T2A-mTFPnls, Prrx1enh-CreER
• Transgene: Tg(Prrx1-mTFP1,-cre/ERT2)1Etnka Location: unknown
• Alliance: Tg(Prrx1-mTFP1,-cre/ERT2)1Etnka page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Prrx1-mTFP1,-cre/ERT2)1Etnka expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Prrx1 (MGI:97712)

• Mutation details: A transgene consists of the 2.4 kb mouse Prrx1 enhancer followed by the b-globin intron and nuclear-localized teal fluorescent protein-1 (mTFP1-nls), a T2A self-cleaving peptide, and CreERT2. Six founder animals were generated and a single line with the ability to induce the recombination of LoxP reporter lines only after administration of tamoxifen was established and used for the studies. (J:337818)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Prrx1 (mouse) Summary of all recombinase alleles driven by Prrx1. Comparative matrix view of recombinase activities Alliance mouse Prrx1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:337818 Currie JD, et al., The Prrx1 limb enhancer marks an adult subpopulation of injury-responsive dermal fibroblasts. Biol Open. 2019;8(7):bio043711
• All: 1 reference(s)