Del(17Scaf8-Pde10a)2Yey
Targeted Allele Detail

Summary

• Symbol: Del(17Scaf8-Pde10a)2Yey
• Name: deletion, chromosome 17, Y Yu
• MGI ID: MGI:7509492
• Synonyms: Df(17)2
• Gene: Del(17Scaf8-Pde10a)2Yey Location: unknown Genetic Position: Chr17, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:337878
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intergenic deletion
• Del(17Scaf8-Pde10a)2Yey involves 2 genes/genome features (Scaf8, Pde10a) View all
• Mutation details: Chromosome-engineering cassettes were inserted into mouse Chromosome 17, bracketing a span between the SR-related CTD-associated factor 8 (Scaf8) gene and the phosphodiesterase 10A (Pde10a) gene. The cassette placed at the proximal locus (MICER clone MHPN155l15) was targeted upstream of Scaf8 and contained a neomycin resistance gene, a loxP site, a 5' portion of an HPRT minigene, and a tyrosinase minigene. The cassette placed at the distal locus (MICER clone MHPP338g19) was targeted downstream of the Pde10a gene and contained an agouti transgene, a 3; portion of an HPRT minigene, a loxP site and puromycin resistance gene. Double-targeted ES cells were transiently transfected with the cre recombinase expression vector pOG231. (J:337878)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(17Scaf8-Pde10a)2Yey Mutation: 1 strain or line available

References

• Original: J:337878 Xing Z, et al., Dissection of a Down syndrome-associated trisomy to separate the gene dosage-dependent and -independent effects of an extra chromosome. Hum Mol Genet. 2023 Jun 19;32(13):2205-2218
• All: 1 reference(s)