Myh6^em2(cre)Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Myh6^em2(cre)Smoc
• Name: myosin, heavy polypeptide 6, cardiac muscle, alpha; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
• MGI ID: MGI:7510097
• Synonyms: Myh6-Cre, Myh6^em(Cre)1Smoc
• Gene: Myh6 Location: Chr14:55179378-55204384 bp, - strand Genetic Position: Chr14, 28.01 cM
• Alliance: Myh6^em2(cre)Smoc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Myh6^em2(cre)Smoc expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myh6 (MGI:97255)

• Mutation details: The CRISPR/Cas9 technology was used to insert the internal ribosome entry site (IRES)-Cre cassette, the woodchuck hepatitis virus posttranscriptional regulatory element (wpre), and a polyA sequence between the translational stop codon and the 3' UTR of the endogenous Myh6 gene. (J:337240)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Myh6 (mouse) Summary of all recombinase alleles driven by Myh6. Comparative matrix view of recombinase activities Alliance mouse Myh6 gene page

Expression

In Mice Carrying this Mutation:

29 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myh6 Mutation: 206 strains or lines available

References

• Original: J:337240 Huang X, et al., Generation and characterization of a Myh6-driven Cre knockin mouse line. Transgenic Res. 2021 Dec;30(6):821-835
• All: 2 reference(s)