Zfp541^em1Fcw
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zfp541^em1Fcw
• Name: zinc finger protein 541; endonuclease-mediated mutation 1, Fengchao Wang
• MGI ID: MGI:7511804
• Gene: Zfp541 Location: Chr7:15795739-15830259 bp, + strand Genetic Position: Chr7, 8.74 cM
• Alliance: Zfp541^em1Fcw page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 2297-bp deletion encompassing exon 3. Western blot analysis confirmed absence of protein in homozygotes. (J:338159)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp541 Mutation: 48 strains or lines available

References

• Original: J:338159 Li Y, et al., The ZFP541-KCTD19 complex is essential for pachytene progression by activating meiotic genes during mouse spermatogenesis. J Genet Genomics. 2022 Nov;49(11):1029-1041
• All: 1 reference(s)