Kctd19^em1Fcw
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kctd19^em1Fcw
• Name: potassium channel tetramerisation domain containing 19; endonuclease-mediated mutation 1, Fengchao Wang
• MGI ID: MGI:7511806
• Gene: Kctd19 Location: Chr8:106109439-106140134 bp, - strand Genetic Position: Chr8, 53.04 cM
• Alliance: Kctd19^em1Fcw page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 104-bp deletion within exon 2. Western blot analysis confirmed absence of protein in homozygotes. (J:338159)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kctd19 Mutation: 52 strains or lines available

References

• Original: J:338159 Li Y, et al., The ZFP541-KCTD19 complex is essential for pachytene progression by activating meiotic genes during mouse spermatogenesis. J Genet Genomics. 2022 Nov;49(11):1029-1041
• All: 1 reference(s)