Cmtm3^em1Wlh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cmtm3^em1Wlh
• Name: CKLF-like MARVEL transmembrane domain containing 3; endonuclease-mediated mutation 1, WenLing Han
• MGI ID: MGI:7511808
• Synonyms: Cmtm3^-
• Gene: Cmtm3 Location: Chr8:105066042-105074304 bp, + strand Genetic Position: Chr8, 53.04 cM
• Alliance: Cmtm3^em1Wlh page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Not Specified
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a null allele, as confirmed by Western blot analysis. Molecular details were not specified. (J:338327)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cmtm3 Mutation: 13 strains or lines available

References

• Original: J:338327 Ye J, et al., CMTM3 deficiency induces cardiac hypertrophy by regulating MAPK/ERK signaling. Biochem Biophys Res Commun. 2023 Jul 30;667:162-169
• All: 1 reference(s)