Dmp1^tm1(cre)Msue
Targeted Allele Detail

Summary

• Symbol: Dmp1^tm1(cre)Msue
• Name: dentin matrix protein 1; targeted mutation 1, Makoto Suematsu
• MGI ID: MGI:7513837
• Synonyms: Dmp1-T2A-Cre
• Gene: Dmp1 Location: Chr5:104350479-104361968 bp, + strand Genetic Position: Chr5, 50.61 cM
• Alliance: Dmp1^tm1(cre)Msue page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:338540
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Dmp1^tm1(cre)Msue expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Dmp1 (MGI:94910)

• Mutation details: A T2A-Cre followed by a frt-flanked neo-selection cassette was inserted at the end of the exon 6 into the 3' UTR of the Dmp1 gene by homologous recombination in the ES cells. Western blot analyses indicated Cre recombinase was expressed specifically in bone and tooth with weak expression also in the brain, muscle, and testes. (J:338540)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Dmp1 (mouse) Summary of all recombinase alleles driven by Dmp1. Comparative matrix view of recombinase activities Alliance mouse Dmp1 gene page

Expression

In Mice Carrying this Mutation:

24 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dmp1 Mutation: 42 strains or lines available

References

• Original: J:338540 Nakamura T, et al., Generation of bicistronic Dmp1-Cre knock-in mice using a self-cleaving 2A peptide. J Bone Miner Metab. 2023 Jul;41(4):470-480
• All: 1 reference(s)