Tbl1xr1^{tm1c(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Tbl1xr1^{tm1c(EUCOMM)Hmgu}
• Name: transducin (beta)-like 1X-linked receptor 1; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:7514121
• Synonyms: Tbl1xr1^KO
• Gene: Tbl1xr1 Location: Chr3:22130816-22270758 bp, + strand Genetic Position: Chr3, 7.58 cM
• Alliance: Tbl1xr1^{tm1c(EUCOMM)Hmgu} page
• IMPC: Tbl1xr1 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:292118
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 22243501 of Chromosome 3 upstream of critical exon 5 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 5 at position 22244776. Exon 5 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking exon 5. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:292118)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbl1xr1 Mutation: 321 strains or lines available

References

• Original: J:292118 Venturutti L, et al., TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate. Cell. 2020 Jul 23;182(2):297-316.e27
• All: 1 reference(s)