Gt(ROSA)26Sor^{tm1.1(Acrv1-icre)Jcoc}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1.1(Acrv1-icre)Jcoc}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Julie Cocquet
• MGI ID: MGI:7514846
• Synonyms: Acrv1-iCre, Rosa26^Acrv1-iCre
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1.1(Acrv1-icre)Jcoc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:338406
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1.1(Acrv1-icre)Jcoc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Acrv1 (MGI:104590)

• Mutation details: The cDNA of iCre recombinase gene under the control of the mouse Acrv1 promoter sequence and hygromycin-resistant cassette, flanked by flippase recognition target sites, was inserted into the Gt(ROSA)26Sor locus. After germline transmission, the mice were crossed with the Flp-deleter line to eliminate the hygromycin cassette. (J:338406)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Acrv1 (mouse) Summary of all recombinase alleles driven by Acrv1. Comparative matrix view of recombinase activities Alliance mouse Acrv1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:338406 Gobe C, et al., Generation and Characterization of a Transgenic Mouse That Specifically Expresses the Cre Recombinase in Spermatids. Genes (Basel). 2023 Apr 27;14(5)
• All: 1 reference(s)