Nrl^{tm1(cre/ERT2)Jpea}
Targeted Allele Detail

Summary

• Symbol: Nrl^{tm1(cre/ERT2)Jpea}
• Name: neural retina leucine zipper gene; targeted mutation 1, Jillian N Pearring
• MGI ID: MGI:7514918
• Synonyms: Nrl:CreERT2
• Gene: Nrl Location: Chr14:55756973-55762438 bp, - strand Genetic Position: Chr14, 28.19 cM
• Alliance: Nrl^{tm1(cre/ERT2)Jpea} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:338794
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Nrl^{tm1(cre/ERT2)Jpea} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Nrl (MGI:102567)

• Mutation details: An internal ribosome entry site (IRES), a tamoxifen-inducible CreERT2, and a neomycin cassette were inserted behind the stop codon for the Nrl gene within exon 4 by homologous recombination in the ES cells. (J:338794)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nrl (mouse) Summary of all recombinase alleles driven by Nrl. Comparative matrix view of recombinase activities Alliance mouse Nrl gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrl Mutation: 18 strains or lines available

References

• Original: J:338794 Thorson MT, et al., Nrl:CreERT2 mouse model to induce mosaic gene expression in rod photoreceptors. Front Mol Neurosci. 2023;16:1161127
• All: 1 reference(s)