Fcgr1^{em1.1(cre)Moli}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fcgr1^{em1.1(cre)Moli}
• Name: Fc receptor, IgG, high affinity I; endonuclease-mediated mutation 1, Ming O Li
• MGI ID: MGI:7516071
• Synonyms: Fcgr1-cre
• Gene: Fcgr1 Location: Chr3:96190225-96201285 bp, - strand Genetic Position: Chr3, 41.72 cM
• Alliance: Fcgr1^{em1.1(cre)Moli} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:338195
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase, Reporter)
• Mutation: Insertion
• Fcgr1^{em1.1(cre)Moli} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Fcgr1 (MGI:95498)

• Mutation details: The targeting construct inserted IRES, tdTomato, T2A self-cleaving peptide, iCre recombinase, and an FRT site-flanked PGK-NEO-BGHpA cassette downstream of the stop codon of the Fcgr1 gene by CRISPRCas9-mediated homologous recombination in mouse ES cells. Mice harboring the targeted allele were subsequently crossed with Rosa26FLPe mice to remove the NEO cassette. (J:338195)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Fcgr1 (mouse) Summary of all recombinase alleles driven by Fcgr1. Comparative matrix view of recombinase activities Alliance mouse Fcgr1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fcgr1 Mutation: 35 strains or lines available

Notes

Lentiviral gene trap injected into zygotes.

References

• Original: J:338195 Zhang X, et al., Reprogramming tumour-associated macrophages to outcompete cancer cells. Nature. 2023 Jul;619(7970):616-623
• All: 1 reference(s)