Svep1^em1Nost
Endonuclease-mediated Allele Detail

Summary

• Symbol: Svep1^em1Nost
• Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1; endonuclease-mediated mutation 1, Nathan O Stitziel
• MGI ID: MGI:7516157
• Synonyms: Svep1^2699G, Svep^G
• Gene: Svep1 Location: Chr4:58042796-58206596 bp, - strand Genetic Position: Chr4, 31.87 cM, cytoband B-C2
• Alliance: Svep1^em1Nost page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Single point mutation
• Mutation details: Aspartic acid codon 2699 (GAT) in exon 38 was changed to glycine (GGT) (p.D2699G) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation is the equivalent of the human p.D2702G mutation associated with coronary artery disease (CAD). (J:304349)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Svep1 Mutation: 169 strains or lines available

References

• Original: J:304349 Jung IH, et al., SVEP1 is a human coronary artery disease locus that promotes atherosclerosis. Sci Transl Med. 2021 Mar 24;13(586)
• All: 1 reference(s)