Septin14^em1.1Plk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Septin14^em1.1Plk
• Name: septin 14; endonuclease-mediated mutation 1.1, Pao-Lin Kuo
• MGI ID: MGI:7517009
• Gene: Septin14 Location: Chr5:129760455-129782048 bp, - strand Genetic Position: Chr5, 68.24 cM
• Alliance: Septin14^em1.1Plk page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR/cas9-mediated recombination using guide RNAs inserted loxP sites surrounding exons 4 and 5. Cre mediated recombination removed exons 4 and 5. RT-PCR analysis confirmed the absence of mRNA expression in hippocampus and cerebellum tissues from homozygous mice. (J:338866)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Septin14 Mutation: 24 strains or lines available

References

• Original: J:338866 Chen KR, et al., Effects of Septin-14 Gene Deletion on Adult Cognitive/Emotional Behavior. Front Mol Neurosci. 2022;15:880858
• All: 1 reference(s)