Pitpna^tm2.1Vab
Targeted Allele Detail

Summary

• Symbol: Pitpna^tm2.1Vab
• Name: phosphatidylinositol transfer protein, alpha; targeted mutation 2.1, Vytas A Bankaitis
• MGI ID: MGI:7520345
• Synonyms: Pitpna^fl
• Gene: Pitpna Location: Chr11:75478923-75519630 bp, + strand Genetic Position: Chr11, 45.92 cM
• Alliance: Pitpna^tm2.1Vab page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263975
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a loxP site upstream of exon 8 and an FRT-flanked neomycin resistance cassette with a 5' loxP site downstream of exon 10. Flp-mediated recombination removed the selection cassette. (J:263975)

Expression

In Mice Carrying this Mutation:

45 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pitpna Mutation: 37 strains or lines available

References

• Original: J:263975 Xie Z, et al., A Golgi Lipid Signaling Pathway Controls Apical Golgi Distribution and Cell Polarity during Neurogenesis. Dev Cell. 2018 Mar 26;44(6):725-740.e4
• All: 2 reference(s)