Rps12^em1.1Nbakr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rps12^em1.1Nbakr
• Name: ribosomal protein S12; endonuclease-mediated mutation 1.1, Nicholas Baker
• MGI ID: MGI:7521935
• Synonyms: Rps12^KO
• Gene: Rps12 Location: Chr10:23661081-23663173 bp, - strand Genetic Position: Chr10, 11.1 cM
• Alliance: Rps12^em1.1Nbakr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A pair of guide-RNAs (gRNAs) are used to introduce loxP sites to intron 1 and intron 3. Cre-mediated recombination removed exons 2-3. (J:338970)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rps12 Mutation: 44 strains or lines available

References

• Original: J:338970 Folgado-Marco V, et al., Haploinsufficiency of the essential gene Rps12 causes defects in erythropoiesis and hematopoietic stem cell maintenance. Elife. 2023 Jun 5;12
• All: 1 reference(s)