Asb4^{em1(cre/ERT2)Awx}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Asb4^{em1(cre/ERT2)Awx}
• Name: ankyrin repeat and SOCS box-containing 4; endonuclease-mediated mutation 1, Allison W Xu
• MGI ID: MGI:7522997
• Synonyms: Asb4^t2aCreERt2
• Gene: Asb4 Location: Chr6:5383386-5433022 bp, + strand Genetic Position: Chr6, 1.99 cM
• Alliance: Asb4^{em1(cre/ERT2)Awx} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Asb4^{em1(cre/ERT2)Awx} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Asb4 (MGI:1929751)

• Mutation details: The t2a-CreERT2 cassette was inserted into the Asb4 locus to replace the STOP codon with CRISPR technology. (J:339272)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Asb4 (mouse) Summary of all recombinase alleles driven by Asb4. Comparative matrix view of recombinase activities Alliance mouse Asb4 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Asb4 Mutation: 30 strains or lines available

References

• Original: J:339272 Vagena E, et al., ASB4 modulates central melanocortinergic neurons and calcitonin signaling to control satiety and glucose homeostasis. Sci Signal. 2022 May 10;15(733):eabj8204
• All: 1 reference(s)